Week Ending June 21, 2022

Alarming increases in deaths from alcoholic cirrhosis in the U.S.
“Alcoholic cirrhosis is an advanced form of alcohol-related liver disease. In the United States between 2010 and 2016, alcohol-related liver disease was the primary cause of nearly 1 in 3 liver transplants, surpassing hepatitis C.”

Coexistence of HBsAg and anti-HBs Results in More Severe Liver Disease in HBV Patients
“Patients with chronic hepatitis B virus (HBV) who have both hepatitis B surface antigen (HBsAg) and antibodies against HBsAg (anti-HBs) face more severe outcomes, including more severe liver fibrosis and cirrhosis.”

CD4 T-Cells Do Not Predict Outcomes of Hepatitis C Treatment in Patients With Cancer
“CD4+ T-cell count was not predictive of treatment outcomes among patients with cancer who received direct-acting antivirals (DAAs) for Hepatitis C virus (HCV) infection, according to a prospective observational study published in Diagnostic Microbiology & Infectious Disease.”

CDC Does Not Find Increase in Pediatric Hepatitis Cases
“A new US Centers for Disease Control and Prevention (CDC) report does not show an increase in pediatric acute hepatitis cases during the COVID-19 pandemic in comparison with pre-pandemic levels.”

Direct-Acting Antivirals as Primary Treatment for Hepatitis C Virus–Associated Indolent Non-Hodgkin Lymphomas: The BArT Study of the Fondazione Italiana Linfomi
“We prospectively treated patients with hepatitis C virus (HCV)–associated indolent lymphomas with genotype-appropriate direct-acting antivirals (DAAs) with the aim to evaluate virologic and hematologic outcomes. No prospective studies in this setting have been published so far.”

Prevalence of Hepatocellular Carcinoma in HIV Patients Co-infected or Triple Infected With Hepatitis B and Hepatitis C in a Community Hospital in South Bronx
“Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) share common modes of transmission; hence HBV and HCV infection are more prevalent among HIV patients. The co-infection with HIV/HBV, HIV/HCV, or HIV/HBV/HCV carries significant morbidity, with higher progression rates to end-stage liver disease or hepatocellular carcinoma (HCC).”

The A-Z of Disease Podcast: Hepatitis B and C