Week Ending March 21, 2022

Hepatocellular Carcinoma: The Viral Hepatitis Pathways
“Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and incidence in the US has tripled in the last four decades. Chronic viral hepatitis is the leading pathway to HCC in the US, followed by noninfectious causes such as obesity, Type-2 Diabetes, Non-alcoholic fatty liver disease (NAFLD), and Non-alcoholic steatohepatitis (NASH) which have been growing rapidly. We will describe viral hepatitis (HCV and HBV) pathways in this blog, and the prevention, diagnosis, and treatment options for these pathways.”

Interventions to enhance testing, linkage to care, and treatment initiation for hepatitis C virus infection: a systematic review and meta-analysis
“Despite the goal set by WHO to eliminate hepatitis C virus (HCV) as a public health threat, uptake of HCV testing and treatment remains low. To achieve this target, evidence-based interventions are needed to address the barriers to care for people with, or at risk of, HCV infection. We aimed to assess the efficacy of interventions to improve HCV antibody testing, HCV RNA testing, linkage to HCV care, and treatment initiation.”

Need HIV/HCV Therapy Plus Drug Use Treatment? Try a Federal Facility
“If you’re looking for a drug treatment center that can also treat HIV and hepatitis C, data presented at the 2022 Conference on Retroviruses and Opportunistic Infections suggest you should consider federal facilities instead of private nonprofit or for-profit centers.”

Testing, Treatment Initiations for Hepatitis C Decreased During the COVID-19 Pandemic
“During the COVID-19 pandemic, testing and treatment initiation rates for patients with hepatitis C virus (HCV) infection significantly decreased in the United States. These findings were published in Clinical Infectious Diseases.”

How to Avoid Reinfection with Hepatitis C
“Hepatitis C is a liver infection caused by the hepatitis C virus. The virus is transmitted from person to person through contact with blood. Hepatitis C reinfection can happen when you’ve received treatment for hepatitis C that cured it or your body cleared the virus on its own, and then you contract the virus again.”

No-click system doubles hepatitis c screening orders, study finds
“Without requiring even one extra mouse click, a randomized clinical trial at the Perelman School of Medicine at the University of Pennsylvania doubled the rate of hepatitis C screenings among the patients for whom they’re recommended. The study simply made the screening a default order for patients who met guidelines at two different hospitals, and compared it to a system that required doctors – through extra steps – to proactively agree to make an order. When made the default, screenings jumped from 42 percent to roughly 80 percent, according to the study, published today in JAMA Network Open.”

To Engage Injection Drug Users in HCV Care, Go to Where They Are
“For injection drug users with hepatitis C virus (HCV) infection, providing treatment opportunities within a local needle exchange program can provide care to more patients and eventually cure more patients, a new study suggests.”

Effect of alcohol on clinical complications of hepatitis virus-induced liver cirrhosis: a consecutive ten-year study
“Although coexisting alcohol-induced liver disease and hepatitis B or C virus-induced liver cirrhosis (ALD + HBV or ALD + HCV) has been the center of recent hepatology researches, numerous controversies still persist. This study aimed to showcase the influence of alcohol on the laboratory values and on the clinical outcomes of patients with hepatitis B and C virus-induced liver cirrhosis.”