Caring Ambassadors Hepatitis C Program Newsletter

 

www.HepCChallenge.org

July 2010

 

Clinical Trials, Cohort Studies, Pilot Studies

 

Two week induction of interferon-beta followed by pegylated interferon alpha-2b and ribavirin for chronic infection with hepatitis C. Matsui K, Iwabuchi S, Shimizu H, et al. Hepatol Res. 2010 Jun 8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20557368

 

Identifying hepatitis C virus genotype 2/3 patients who can receive a 16-week abbreviated course of peginterferon alfa-2a (40KD) plus ribavirin. Diago M, Shiffman ML, Bronowicki JP, et al. Hepatology. 2010 Jun;51(6):1897-903.

http://www.ncbi.nlm.nih.gov/pubmed/20196118

 

Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients with genotype 1b and high virus load. Arase Y, Suzuki F, Akuta N, et al. Intern Med. 2010;49(11):957-63. Epub 2010 Jun 1.

http://www.ncbi.nlm.nih.gov/pubmed/20519809

 

Availability of body art facilities and body art piercing do not predict hepatitis C acquisition among injection drug users in Montreal, Canada: Results from a cohort study.

Bruneau J, Daniel M, Kestens Y, Abrahamowicz M, Zang G. Int J Drug Policy. 2010 Jun 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20541926

 

Metabolic disorders associated with chronic hepatitis C: impact of genotype and ethnicity.

Sersté T, Nkuize M, Moucari R, et al. Liver Int. 2010 Jun 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20536721

 

Influence of body mass index on outcome of pediatric chronic hepatitis c virus infection. Delgado-Borrego A, Healey D, Negre B, et al. J Pediatr Gastroenterol Nutr. 2010 Jun 3. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20531022

 

Hepatitis C virus infection is significantly associated with malignant lymphoma in Taiwan, particularly with nodal and splenic marginal zone lymphomas. Chuang SS, Liao YL, Chang ST, et al. J Clin Pathol. 2010 Jun 7. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20530156

 

Nail changes in patients with liver disease. Salem A, Gamil H, Hamed M, Galal S. J Eur Acad Dermatol Venereol. 2010 Jun;24(6):649-54. Epub 2009 Nov 2.

http://www.ncbi.nlm.nih.gov/pubmed/19888943

 

The H63D genetic variant of the HFE gene is independently associated with the virological response to interferon and ribavirin therapy in chronic hepatitis C. Carneiro MV, Souza FF, Teixeira AC, et al. Eur J Gastroenterol Hepatol. 2010 Jun 15. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20555268

 

Basic and Applied Science, Pre-Clinical Studies

 

Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. Thompson AJ, Fellay J, Patel K, et al. Gastroenterology. 2010 Jun 11. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20547162

 

Positive selection of core 70Q variant genotype 1b hepatitis C virus strains induced by pegylated interferon and ribavirin. Kurbanov F, Tanaka Y, Matsuura K, et al. J Infect Dis. 2010 Jun 1;201(11):1663-71.

http://www.ncbi.nlm.nih.gov/pubmed/20420509

 

Wild-type hepatitis C virus core inhibits the initiation of antigen-specific T- and B-cell immune responses in BALB/c mice. Zhu W, Chang Y, Wu C, Han Q, Pei R, Lu M, Chen X. Clin Vaccine Immunol. 2010 Jun 2. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20519445

 

PSI-7851, a Pronucleotide of {beta}-D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine Monophosphate: A potent and pan-genotype inhibitor of hepatitis c virus replication.

Lam AM, Murakami E, Espiritu C, et al. Antimicrob Agents Chemother. 2010 Jun 1. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20516278

 

Phosphoramidate ProTides of 2'-C-Methylguanosine as highly potent inhibitors of hepatitis c virus. Study of their in vitro and in vivo properties. McGuigan C, Gilles A, Madela K, et al. J Med Chem. 2010 Jun 8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20527890

 

Prediction of prognostic biomarkers for Interferon-based therapy to Hepatitis C Virus patients : a metaanalysis of the NS5A protein in subtypes 1a, 1b, and 3a. Elhefnawi MM, Zada S, El-Azab IA. Virol J. 2010 Jun 15;7(1):130. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20550652

 

Association of NKG2A with treatment for chronic hepatitis C virus infection. Harrison RJ, Ettorre A, Little AM, Khakoo SI. Clin Exp Immunol. 2010 Jun 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20550548

 

Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone. Chandra PK, Hazari S, Poat B, et al.

http://www.ncbi.nlm.nih.gov/pubmed/20529250

Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection. Li JH, Lao XQ, Tillmann HL, et al. Hepatology. 2010 Jun;51(6):1904-11.

http://www.ncbi.nlm.nih.gov/pubmed/20235331

 

Hepatocyte growth factor and chronic hepatitis C. Marín-Serrano E, Rodríguez-Ramos C, Díaz-García F, et al. Rev Esp Enferm Dig. 2010 Jun;102(6):365-71.

http://www.ncbi.nlm.nih.gov/pubmed/20575596

 

HIV/HCV Coinfection

 

The impact of HIV/HCV co-infection on health care utilization and disability: Results of the ACTG Longitudinal Linked Randomized Trials (ALLRT) Cohort.

Linas BP, Wang B, Smurzynski M, et al. J Viral Hepat. 2010 Jun 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20546501

 

Insulin resistance impairs response to interferon plus ribavirin in patients coinfected with HIV and hepatitis C virus. Ryan P, Resino S, Miralles P, Cosín J, et al. J Acquir Immune Defic Syndr. 2010 Jun 23. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20577091

 

Clearance of hepatitis C virus RNA from serum in HIV/hepatitis C virus coinfection indicates eradication from peripheral blood mononuclear cells. Page EE, Cox A, Atkins M, Nelson MR. AIDS. 2010 Jun 1;24(9):1267-71.

http://www.ncbi.nlm.nih.gov/pubmed/20386424

 

Impact of hepatitis C virus coinfection on HAART in HIV-infected individuals: multi-centric observation cohort. Fuping G, Wei L, Yang H, et al. J Acquir Immune Defic Syndr. 2010 Jun;54(2):137-42.

http://www.ncbi.nlm.nih.gov/pubmed/20431395

 

Safety, tolerability, and mechanisms of antiretroviral activity of pegylated interferon Alfa-2a in HIV-1-monoinfected participants: a phase II clinical trial. Asmuth DM, Murphy RL, Rosenkranz SL, et al. J Infect Dis. 2010 Jun 1;201(11):1686-96.

http://www.ncbi.nlm.nih.gov/pubmed/20420510

 

The effects of opiate use and hepatitis C virus infection on risk of diabetes mellitus in the Women's Interagency HIV Study. Howard AA, Hoover DR, Anastos K, et al. J Acquir Immune Defic Syndr. 2010 Jun;54(2):152-9.

http://www.ncbi.nlm.nih.gov/pubmed/20190642

 

Hepatitis C transmission, prevention, and treatment knowledge among patients with HIV. Proeschold-Bell RJ, Blouin R, Reif S, et al. South Med J. 2010 Jun 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20531062

 

Hepatitis B and hepatitis C seroprevalence in children receiving antiretroviral therapy for human immunodeficiency virus-1 infection in China, 2005-2009. Zhou S, Zhao Y, He Y, et al. J Acquir Immune Defic Syndr. 2010 Jun;54(2):191-6.

http://www.ncbi.nlm.nih.gov/pubmed/20032784

 

Interleukin-27, an anti-HIV-1 cytokine, inhibits replication of hepatitis C virus. Frank AC, Zhang X, Katsounas A, et al. J Interferon Cytokine Res. 2010 Jun;30(6):427-31. Bharucha JP,

http://www.ncbi.nlm.nih.gov/pubmed/20235668

 

Need to improve routine HIV testing of U.S. Veterans in care: Results of an internet survey.

Valdiserri RO, Nazi K, McInnes DK, Ross D, Kinsinger L. J Community Health. 2010 Jun;35(3):215-9.

http://www.ncbi.nlm.nih.gov/pubmed/20146092

 

Complementary and Alternative Medicine

 

Acupuncture for depression and myalgia in patients with hepatitis: an observational study.

Tufan ZK, Arslan H, Yildiz F, et al. Acupunct Med. 2010 Jun 7. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20530097

 

Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C.

Gomez EV, Perez YM, Sanchez HV, et al. World J Gastroenterol. 2010 Jun 7;16(21):2638-47.

http://www.ncbi.nlm.nih.gov/pubmed/20518086

 

Colchicine reduces procollagen III and increases pseudocholinesterase in chronic liver disease. Muntoni S, Rojkind M, Muntoni S. World J Gastroenterol. 2010 Jun 21;16(23):2889-94.

http://www.ncbi.nlm.nih.gov/pubmed/20556834

 

Epidemiology, Diagnostics, and Miscellaneous Works

 

A novel duplex real-time reverse transcriptase-polymerase chain reaction assay for the detection of hepatitis C viral RNA with armored RNA as internal control. Meng S, Li J. Virol J. 2010 Jun 7;7(1):117. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20529244

 

Soluble inflammatory markers as predictors of liver histological changes in patients with chronic hepatitis C virus infection. Moura AS, Carmo RA, Teixeira AL, Leite VH, Rocha MO. Eur J Clin Microbiol Infect Dis. 2010 Jun 18. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20559676

 

Non-invasive index for predicting significant liver fibrosis: comparison of diagnostic performances in patients with chronic hepatitis B and C. Cheong JY, Um SH, Seo YS, et al. Dig Dis Sci. 2010 Jun 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20585981

 

Viral response to specifically targeted antiviral therapy for hepatitis C and the implications for treatment success. Cooper C. Can J Gastroenterol. 2010 Jun;24(6):385-90.

http://www.ncbi.nlm.nih.gov/pubmed/20559582

 

Pharmacy participation in non-prescription syringe sales in Los Angeles and San Francisco Counties, 2007. Cooper EN, Dodson C, Stopka TJ, et al.  J Urban Health. 2010 Jun 12. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20549568

 

Current risks of occupational blood-borne viral infection. Mohebati A, Davis JM, Fry DE. Surg Infect (Larchmt). 2010 Jun;11(3):325-31.

http://www.ncbi.nlm.nih.gov/pubmed/20528133

 

Chronic hepatitis C in the state prison system: insights into the problems and possible solutions. Imperial JC. Expert Rev Gastroenterol Hepatol. 2010 Jun;4(3):355-64.

http://www.ncbi.nlm.nih.gov/pubmed/20528122

 

Timing of hepatitis C antiviral therapy in patients with advanced liver disease: a decision analysis model. Saab S, Hunt DR, Stone MA, McClune A, Tong MJ. Liver Transpl. 2010 Jun;16(6):748-59.

http://www.ncbi.nlm.nih.gov/pubmed/20517909

 

Development of a low-cost real-time reverse transcriptase-polymerase chain reaction technique for the detection and quantification of hepatitis C viral load. Shahzamani K, Merat S, Rezvan H, et al. Clin Chem Lab Med. 2010 Jun;48(6):777-84.

http://www.ncbi.nlm.nih.gov/pubmed/20218905

 

How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides. Ciesek S, Friesland M, Steinmann J, et al. J Infect Dis. 2010 Jun 15;201(12):1859-66.

http://www.ncbi.nlm.nih.gov/pubmed/20441517

 

The role of physician and nurse attitudes in the health care of injecting drug users.

Brener L, Von Hippel W, Kippax S, Preacher KJ. Subst Use Misuse. 2010 Jun;45(7-8):1007-18.

http://www.ncbi.nlm.nih.gov/pubmed/20441447

 

Patient preferences and assessment of likely adherence to hepatitis C virus treatment.

Brett Hauber A, Mohamed AF, Beam C, Medjedovic J, Mauskopf J. J Viral Hepat. 2010 Jun 22. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20579276

 

Hepatitis C virus infections from unsafe injection practices at an endoscopy clinic in Las Vegas, Nevada, 2007-2008. Fischer GE, Schaefer MK, Labus BJ, et al. Clin Infect Dis. 2010 Jun 24. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20575663

 

Epidemiology, Surveillance, and Prevention of Hepatitis C Virus Infections in Hemo-dialysis Patients. Patel PR, Thompson ND, Kallen AJ, Arduino MJ. Am J Kidney Dis. 2010 Jun 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20570422

 

The Ribavirin Pregnancy Registry: Findings after 5 years of enrollment, 2003-2009.

Roberts SS, Miller RK, Jones JK, et al. Birth Defects Res A Clin Mol Teratol. 2010 Jun 17. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20564430