Caring Ambassadors Hepatitis C Program Newsletter

July 2009


Clinical Trials, Cohort Studies, Pilot Studies


Interferon induced retinopathy and its risk in patients with diabetes and hypertension undergoing treatment for chronic hepatitis C virus infection. D Panetta J, Gilani N. Aliment Pharmacol Ther. 2009 Jun 22. [Epub ahead of print]


Economic evaluation of early monotherapy versus delayed monotherapy or combination therapy in patients with acute hepatitis C in Germany. Dintsios CM, Haverkamp A, Wiegand J, et al. Eur J Gastroenterol Hepatol. 2009 Jun 22. [Epub ahead of print]


Extended treatment duration of peginterferon-alpha2b plus ribavirin for 72 and 96 weeks in hepatitis C genotype 1-infected late responders. Nagaki M, Shimizu M, Sugihara JI, et al. Aliment Pharmacol Ther. 2009 May 26. [Epub ahead of print]


A randomised trial of pegylated-interferon-alpha-2a plus ribavirin with or without amantadine in treatment-naïve or relapsing chronic hepatitis C patients. Langlet P, D'Heygere F, Henrion J, et al. Aliment Pharmacol Ther. 2009 May 26. [Epub ahead of print]


Decline in male sexual desire, function, and satisfaction during and after antiviral therapy for chronic hepatitis C. Dove LM, Rosen RC, Ramcharran D, Wahed AS, Belle SH, Brown RS, Hoofnagle JH; Virahep-C Study Group. Gastroenterology. 2009 Jun 12. [Epub ahead of print]


Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C.Honda T, Katano Y, Shimizu J, et al. Liver Int. 2009 Jun 12. [Epub ahead of print]


Impact of ribavirin plasma level on sustained virological response in patients treated with pegylated interferon and ribavirin for chronic hepatitis C. Breilh D, Foucher J, Castéra L, et al. Aliment Pharmacol Ther. 2009 Jun 11. [Epub ahead of print]


Factors associated with the progression of hepatic fibrosis in end-stage kidney disease patients with hepatitis C virus infection. Becker VR, Badiani RG, Lemos LB, et al. Eur J Gastroenterol Hepatol. 2009 Jun 11. [Epub ahead of print]


Development of hepatocellular carcinoma in elderly patients with chronic hepatitis C with or without elevated aspartate and alanine aminotransferase levels. Kobayashi M, Suzuki F, Akuta N, et al. J Gastroenterol. 2009 Jun 11:1-9. [Epub ahead of print]


Response to hepatitis A and B vaccine alone or in combination in patients with chronic hepatitis C virus and advanced fibrosis. Kramer ES, Hofmann C, Smith PG, Shiffman ML, Sterling RK. Dig Dis Sci. 2009 Jun 11. [Epub ahead of print]


Hepatitis C virus infection and the risk of coronary disease. Butt AA, Xiaoqiang W, Budoff M, Leaf D, Kuller LH, Justice AC. Clin Infect Dis. 2009 Jul 15;49(2):225-32


Light and moderate alcohol consumption significantly reduces the prevalence of fatty liver in the Japanese male population. Gunji T, Matsuhashi N, Sato H, et al. Am J Gastroenterol. 2009 Jun 23. [Epub ahead of print]


Quality of life, depression, and cytokine patterns in patients with chronic hepatitis C treated with antiviral therapy. Falasca K, Mancino P, Ucciferri C, et al. Clin Invest Med. 2009 Jun 1;32(3):E212-8.


Basic and Applied Science, Pre-Clinical Studies


Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study. Okanoue T, Itoh Y, Hashimoto H, et al J Gastroenterol. 2009 Jun 11. [Epub ahead of print]


Differences in viral kinetics between genotypes 1 and 2 of hepatitis C virus after single administration of standard interferon-alpha.  Toyoda H, Kumada T, Kiriyama S, et al. J Med Virol. 2009 Jun 23;81(8):1354-1362. [Epub ahead of print]


Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection. Sillanpaa M, Melen K, Porkka P, et al. Virol J. 2009 Jun 23;6(1):84. [Epub ahead of print]


Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regiment. Alekseeva E, Sominskaya I, Skrastina D, et al. Genet Vaccines Ther. 2009 Jun 8;7(1):7. [Epub ahead of print]


Tight junction-associated protein occludin is required for a post-binding step in hepatitis C virus entry and infection. Benedicto I, Molina-Jiménez F, Bartosch B, et al. J Virol. 2009 Jun 10. [Epub ahead of print]


Presence of HCV-RNA after ultracentrifugation of serum samples during the follow-up of chronic hepatitis C patients with a sustained virological response may predict reactivation of hepatitis C virus infection. Castillo I, Bartolomé J, Quiroga JA, Barril G, Carreño V. Aliment Pharmacol Ther. 2009 Jun 11. [Epub ahead of print]


HIV/HCV Coinfection


Long-term serologic follow-up of isolated hepatitis B core antibody in HIV-infected and HIV-uninfected women. French AL, Lin MY, Evans CT, et al. Clin Infect Dis. 2009 Jul 1;49(1):148-54.


Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. Urbanus AT, van de Laar TJ, Stolte IG, et al. AIDS. 2009 Jun 17. [Epub ahead of print]


Liver stiffness as a predictor of esophageal varices requiring therapy in HIV/hepatitis C virus-coinfected patients with cirrhosis. Pineda JA, Recio E, Camacho A, et al. J Acquir Immune Defic Syndr. 2009 May 28. [Epub ahead of print]


Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells. Kottilil S, Yan MY, Reitano KN,et al. Hepatology. 2009 May 6;50(1):34-45. [Epub ahead of print] 


Peginterferon plus ribavirin for chronic hepatitis C in patients with human immune-deficiency virus. Gluud LL, Marchesini E, Iorio A. Am J Gastroenterol. 2009 Jun 9. [Epub ahead of print]


Complementary & Alternative Medicine


Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status. Inoue M, Kurahashi N, Iwasaki M, et al. Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1746-53.


Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C Virus RNA. Takeshita M, Ishida YI, Akamatsu E, et al. J Biol Chem. 2009 Jun 16. [Epub ahead of print]


Epidemiology, Diagnostics, and Miscellaneous Works


Liver biopsies for chronic hepatitis C: Should nonultrasound-guided biopsies be abandoned? Flemming JA, Hurlbut DJ, Mussari B, Hookey LC. Can J Gastroenterol. 2009 Jun;23(6):425-30.


Validation of hepascore, compared with simple indices of fibrosis, in patients with chronic hepatitis C virus infection in United States. Becker L, Salameh W, Sferruzza A, et al.

Zhang K, ng Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Clin Gastroenterol Hepatol. 2009 Jun;7(6):696-701.


Healthcare-associated hepatitis C virus transmission among patients in an abdominal organ transplant center. Thompson ND, Hellinger WC, Kay RS, et al. Transpl Infect Dis. 2009 May 26. [Epub ahead of print]


Increasing public awareness about hepatitis C: development and validation of the brief hepatitis C knowledge scale.  Balfour L, Kowal J, Corace KM, Tasca GA, Krysanski V, Cooper CL, Garber G. Scand J Caring Sci. 2009 Jun 5. [Epub ahead of print]


Hepatitis C performance measure on hepatitis A and B vaccination: Missed opportunities? Hernandez B, Hasson NK, Cheung R. Am J Gastroenterol. 2009 Jun 2. [Epub ahead of print]


Chronic liver disease mortality among male prison inmates in Texas, 1989-2003. Harzke AJ, Baillargeon J, Paar DP, Pulvino J, Murray OJ. Am J Gastroenterol. 2009 Jun;104(6):1412-9. Epub 2009 Apr 21.


Improving access to care by allowing self-referral to a hepatitis C clinic. Doucette KE, Robson V, Shafran S, Kunimoto D. Can J Gastroenterol. 2009 Jun;23(6):421-4.


Prevalence of problem alcohol use among patients attending primary care for methadone treatment. Ryder N, Cullen W, Barry J, Bury G, Keenan E, Smyth BP. BMC Fam Pract. 2009 Jun 11;10(1):42. [Epub ahead of print]


Prevalence and trends of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among blood donors in Iran, 2004 through 2007. Amini Kafi-Abad S, Rezvan H, Abolghasemi H, Talebian A. Transfusion. 2009 Jun 10. [Epub ahead of print]


Effective use of FibroTest to generate decision trees in hepatitis C. Lau-Corona D, Pineda LA, Avilés HH, et al World J Gastroenterol. 2009 Jun 7;15(21):2617-22.

Prevalence of human cytomegalovirus co-infection in patients with chronic viral hepatitis B and C: A comparison of clinical and histological aspects. Bayram A, Ozkur A, Erkilic S. J Clin Virol. 2009 Jun 2. [Epub ahead of print]