Hepatitis C Caring Ambassadors Program Newsletter

September 2005

 

In The News

 

 

AVI BioPharma Initiates Hepatitis C Clinical Trial

http://home.businesswire.com/portal/site/google/index.jsp?ndmViewId=news_view&newsId=20050928005211&newsLang=en

Quilt Shows Victims of Hepatitis C's Silent Onslaught

http://www.detnews.com/2005/metro/0509/16/B01-317112.htm

 

Aethlon Medical Launches Hepatitis-C Clinical Trial

http://www.genengnews.com/news/bnitem.aspx?name=1060340XSL_NEWSML_TO_NEWSML_WEB.xml

 

Naomi Judd Finds Balance, Purpose in Hepatitis Fight

http://www.azcentral.com/arizonarepublic/arizonaliving/articles/0929qajudd0922.html


Pharmacists Able to Detect 'Hidden' Hepatitis C in Drug Users [UK]

http://www.prnewswire.co.uk/cgi/news/release?id=154524

 

Hepatitis C Suit

http://www.wowt.com/news/headlines/1764386.html

 

Hepatitis C Trial Begins

http://www.fremontneb.com/articles/2005/10/04/news/news1.txt


Budget Lacks Hepatitis C Funds for Inmates

http://www.lsj.com/apps/pbcs.dll/article?AID=/20051003/NEWS01/510030328/1001/news

 

Biomarkers Used to Predict Recurrent Disease in Hepatitis C Transplant Patients

http://www.eurekalert.org/pub_releases/2005-10/jws-but100305.php

 

New Data Suggest Vertex's Oral Hepatitis C Virus Protease Inhibitor VX-950 May Reduce Liver Injury; VX-950 Clinical Milestones on Track

http://www.newswire.ca/en/releases/archive/October2005/03/c6578.html

 
Hepatitis C Drug Cost-Effective for Anemia

http://www.sciencedaily.com/upi/index.php?feed=Science&article=UPI-1-20051003-19443500-bc-us-hepdrug.xml

 

Hepatitis C 'Needn't be a Killer'

http://news.bbc.co.uk/1/hi/health/4293592.stm

 

Hepatitis C Threatens New Generation of Egyptians

http://www.alertnet.org/thenews/newsdesk/L05168992.htm


Most Chronic Hepatitis C Patients Will Develop Cirrhosis in Later Life

http://www.xagena.it/news/medicinenews_net_news/e17aeca56fab22ce30ac615e72cc64e5.html

 

Linking MicroRNA to Hepatitis C -Liver-specific microRNA Facilitates Replication of the Virus, Study in Science Shows

http://www.the-scientist.com/news/20050902/01

 

Sex Abuse Suspect May Have Hepatitis C

http://www.ksl.com/?nid=148&sid=107577

 

Surgeon Did not Know Locum had Hepatitis C Virus

http://icbirmingham.icnetwork.co.uk/0100news/0100localnews/tm_objectid=16128875&method=full&siteid=50002&headline=surgeon-did-not-know-locum-had-hepatitis-c-virus--name_page.html

 

 

 

Flamel Technologies Announces Positive Preliminary Results of a Phase I/II Trial of IFN-alpha-XL in Patients with Chronic Hepatitis C Virus Infection

http://www.leaddiscovery.co.uk/prlink.asp?reclink=http://www.flamel.com/pressReleases/20050923.shtml

 

CLINICAL TRIALS, COHORT STUDIES, PILOT STUDIES

 

Clinical presentation of chronic hepatitis C in patients with end-stage renal disease and on hemodialysis versus those with normal renal function.. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16128946&query_hl=108

Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial.. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16136646&query_hl=18

High-dose interferon-alpha2b induction therapy in combination with ribavirin for treatment of chronic hepatitis C in patients with non-response or relapse after interferon-alpha monotherapy. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16149143&query_hl=18

Hepatitis C is a predictor of poorer renal survival in diabetic patients.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16123488&query_hl=18
 
Past excessive alcohol consumption: a major determinant of severe liver disease among newly referred hepatitis C virus infected patients in hepatology reference centers, France, 2001.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16117999&query_hl=18

Gamma-glutamyl transferase (GGT) as an independent predictive factor of sustained virologic response in patients with hepatitis C treated with interferon-alpha and ribavirin.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16082285&query_hl=18
 
Liver enzyme values in injection drug users with chronic hepatitis C. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15951255&query_hl=18
 
Predicting sustained virological responses in chronic hepatitis C patients treated with peginterferon alfa-2a (40 KD)/ribavirin. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15990196&query_hl=18
 
Hepatitis C virus RNA kinetics during the initial 12 weeks treatment with pegylated interferon-alpha 2a and ribavirin according to virological response.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108761&query_hl=18
 
Weight loss during pegylated interferon and ribavirin treatment of chronic hepatitis C*.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108770&query_hl=18

Humoral immune response in acute hepatitis C virus infection. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16080089&query_hl=18
 
Higher doses of peginterferon alpha-2b administered twice weekly improve sustained virological response in difficult-to-treat patients with chronic hepatitis C: results of a pilot randomized study.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108771&query_hl=18
 
Hepatitis C virus infection facilitates gallstone formation. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16105130&query_hl=18
 
Rationale and design of the REPEAT study: a phase III, randomized, clinical trial of peginterferon alfa-2a (40 kDa) plus ribavirin in non-responders to peginterferon alfa-2b (12 kDa) plus ribavirin. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16093865&query_hl=18
 
Pegylated interferon and ribavirin therapy for chronic hepatitis C virus genotype 4 infection.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16032749&query_hl=18

Antiviral activity and safety of 873140, a novel CCR5 antagonist, during short-term monotherapy in HIV-infected adults.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16135896&query_hl=18

Basic and Applied Science, Pre-Clinical Studies

 

Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16077914&query_hl=18

Telomerase reverse transcriptase mRNA expression in peripheral lymphocytes of patients with chronic HBV and HCV infections.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108763&query_hl=18
 
Interferon-alpha suppresses liver cell proliferation in patients with chronic hepatitis C virus infection. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108765&query_hl=18
 
Polymorphisms of the renin-angiotensin system and the severity of fibrosis in chronic hepatitis C virus infection.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108768&query_hl=18

 
Hepatitis C virus-specific reactivity of CD4+-lymphocytes in children born from HCV-infected women.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16023248&query_hl=18

Cytokine profile of peripheral blood mononuclear cells from patients with different outcomes of hepatitis C virus infection. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108769&query_hl=18

GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16019105&query_hl=18
 

Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16023246&query_hl=18

Hepatitis C Virus Genotype 1a NS5A Pretreatment Sequence Variation and Viral Kinetics in African American and White Patients.   http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16107963&query_hl=18
 
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site. 

http://www.jbc.org/cgi/content/abstract/280/33/29765


Serum KL-6 as a novel tumor marker for hepatocellular carcinoma in hepatitis C virus infected patients. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16202647&query_hl=5

Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16146571&query_hl=18
 
Involvement of chemokines and type 1 cytokines in the pathogenesis of hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16142759&query_hl=18

Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16143140&query_hl=18

Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16105128&query_hl=18

Broad Repertoire of the CD4+ Th Cell Response in Spontaneously Controlled Hepatitis C Virus Infection Includes Dominant and Highly Promiscuous Epitopes. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16148104&query_hl=18

Cryoglobulin-associated uptake of hepatitis C virus into human hepatocytes.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16201113&query_hl=5
 
Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16114108&query_hl=18

In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16087668&query_hl=18

LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16037945&query_hl=18
 
Chronic liver injury in rat and man upregulates the novel enzyme angiotensin converting enzyme II.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16166274&query_hl=18

The concentration of sFasL, ICE and IL-1beta in the serum and the liver tissue of chronic HCV infected patients.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16201101&query_hl=5

HIV/HCV Coinfection

 

Transmission of Hepatitis C Virus Among HIV-Positive Homosexual Men and Response to a 24-Week Course of Pegylated Interferon and Ribavirin. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16123680&query_hl=18
 

Impact of hepatitis C virus on immune restoration in HIV-infected patients who start highly active antiretroviral therapy: a meta-analysis.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16080095&query_hl=18

Influence of Hepatitis C Virus Infection on HIV-1 Disease Progression and Response to Highly Active Antiretroviral Therapy. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16107951&query_hl=18
 
Impact of Chronic Viral Hepatitis on Health-Related Quality of Life in HIV: Results from a Nationally Representative Sample. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16128943&query_hl=18
 
Prevalence of hepatitis B and C in pregnant women who are infected with human immunodeficiency virus.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16157150&query_hl=18


Liver injury and changes in hepatitis C Virus (HCV) RNA load associated with protease inhibitor-based antiretroviral therapy for treatment-naive HCV-HIV-coinfected patients: lopinavir-ritonavir versus nelfinavir

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16163639&query_hl=18
 
Increased Hepatocyte Fas Expression and Apoptosis in HIV and Hepatitis C Virus Coinfection.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16206071&query_hl=5

Presence of Hepatitis C Virus (HCV) RNA in the Genital Tracts of HCV/HIV-1-Coinfected Women.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16206070&query_hl=5
 
Slower fibrosis progression in HIV/HCV-coinfected patients with successful HIV suppression using antiretroviral therapy. 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16182404&query_hl=2

Complementary and Alternative Therapies

 

Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16082287&query_hl=18

Chinese Herbal Medicine and Chemotherapy in the Treatment of Hepatocellular Carcinoma: A Meta-analysis of Randomized Controlled Trials .

http://ict.sagepub.com/cgi/content/abstract/4/3/219

 

Miscellaneous Works

 

Susceptibility to hepatitis A in patients with chronic liver disease due to hepatitis C virus infection: missed opportunities for vaccination.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16104047&query_hl=18
 
Irritability rather than depression during interferon treatment is linked to increased tryptophan catabolism. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16204437&query_hl=5
 
Description of a new hepatitis C risk assessment tool. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16186472&query_hl=18

Demographic, HIV risk behavior, and health status characteristics of "crack" cocaine injectors compared to other injection drug users in three New England cities. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16171952&query_hl=18
 
When Does Mother to Child Transmission of Hepatitis C Virus Occur?  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16121099&query_hl=18

Physical and psychosocial contributors to quality of life in veterans with hepatitis C not on antiviral therapy.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16082286&query_hl=18

Ethical challenges in the care of persons with hepatitis C infection: a pilot study to enhance informed consent with veterans. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16145183&query_hl=18

Comparison of characteristics of treated and non-treated patients with Hepatitis C infection.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16136612&query_hl=18
  
Changes in epidemiological patterns of HCV infection and their impact on liver disease over the last 20 years in Greece. 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108773&query_hl=18

Future trends of HCV-related cirrhosis and hepatocellular carcinoma under the currently available treatments.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16108772&query_hl=18